Assay Detail
Functional
CHEMBL3268811
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Antitrypanosomal activity against Trypanosoma cruzi Sylvio X-10 amastigotes infected in African green monkey Vero cells assessed as eradication of amastigotes after 72 hrs by Giemsa staining-based assay
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.82 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | 4.0 | 2 | 6.35 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 3300.0 | nM | 5.48 |