Assay Detail
Functional
CHEMBL3282590
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Antibacterial activity against sensitive Lactobacillus casei ATCC 7469 assessed as reduction
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Lacticaseibacillus casei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.79 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 10.22 |
| CHEMBL129788 | — | — | 1 | 7.68 |
| CHEMBL1877296 | — | — | 1 | 7.55 |
| CHEMBL268584 | — | — | 1 | 7.40 |
| CHEMBL1213592 | CLOCIGUANIL | 2.0 | 1 | 7.24 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.72 |
| CHEMBL3249753 | — | — | 1 | 6.70 |
| CHEMBL3272425 | — | — | 1 | 6.60 |
| CHEMBL414017 | — | — | 1 | 6.40 |
| CHEMBL56129 | — | — | 1 | 6.03 |
| CHEMBL3272426 | — | — | 1 | 6.00 |
| CHEMBL3272427 | — | — | 1 | 5.52 |
| CHEMBL568202 | — | — | 1 | 5.50 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.29 |
| CHEMBL3272428 | — | — | 1 | 5.24 |
| CHEMBL2028354 | — | — | 1 | 5.22 |
| CHEMBL285373 | — | — | 1 | 5.00 |
| CHEMBL31695 | — | — | 1 | 4.92 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 4.79 |
| CHEMBL530718 | — | — | 1 | 4.56 |
| CHEMBL3272430 | — | — | 1 | 4.52 |
| CHEMBL2009682 | — | — | 1 | 4.51 |
| CHEMBL3272432 | — | — | 1 | 4.32 |
| CHEMBL1999063 | MENOCTONE | 2.0 | 1 | 4.21 |
| CHEMBL1939337 | — | — | 1 | 4.19 |
| CHEMBL1992508 | — | — | 1 | 4.17 |
| CHEMBL1525826 | SULFALENE | 3.0 | 1 | - |
| CHEMBL437 | SULFATHIAZOLE | 4.0 | 1 | - |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | - |
| CHEMBL446918 | CLOPIDOL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL129788 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1877296 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL268584 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1213592 | CLOCIGUANIL | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3249753 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3272425 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL414017 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL56129 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3272426 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3272427 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL568202 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3272428 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2028354 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL285373 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL31695 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL747 | CYCLOGUANIL | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL530718 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL3272430 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2009682 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3272432 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1999063 | MENOCTONE | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1939337 | — | IC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL1992508 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL170 | QUININE | IC50 | = | 980000.0 | nM | - |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 630000.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 6400000.0 | nM | - |
| CHEMBL1995683 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL3272429 | — | IC50 | = | 3000000.0 | nM | - |
| CHEMBL1043 | DAPSONE | IC50 | = | 314000.0 | nM | - |
| CHEMBL3272431 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL295830 | CYCLOLEUCINE | IC50 | > | 7700000.0 | nM | - |
| CHEMBL1979892 | — | IC50 | = | 2600000.0 | nM | - |
| CHEMBL3182002 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL446918 | CLOPIDOL | IC50 | = | 1700000.0 | nM | - |
| CHEMBL439 | SULFADIAZINE | IC50 | > | 4000000.0 | nM | - |
| CHEMBL437 | SULFATHIAZOLE | IC50 | > | 3900000.0 | nM | - |
| CHEMBL1525826 | SULFALENE | IC50 | = | 8200000.0 | nM | - |