Assay Detail
Functional
CHEMBL3292697
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Cytotoxicity against human HL60 cells assessed as inhibition of proliferation after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.64 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290761 | — | — | 1 | 6.16 |
| CHEMBL3290763 | — | — | 1 | 6.10 |
| CHEMBL3290760 | — | — | 1 | 5.60 |
| CHEMBL3290762 | — | — | 1 | 5.60 |
| CHEMBL3290759 | — | — | 1 | 5.21 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | 4.0 | 1 | 5.19 |
| CHEMBL351769 | ARSANILIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290761 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3290763 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3290760 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3290762 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3290759 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL351769 | ARSANILIC ACID | IC50 | > | 10000.0 | nM | - |