Assay Detail
ADMET
CHEMBL3292789
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Inhibition of CYP3A4 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.35 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3288010 | — | — | 1 | 6.40 |
| CHEMBL3287739 | — | — | 1 | 6.30 |
| CHEMBL3288009 | — | — | 1 | - |
| CHEMBL3288011 | — | — | 1 | - |
| CHEMBL3288027 | — | — | 1 | - |
| CHEMBL3288028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3288010 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3287739 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3288009 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3288011 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3288027 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3288028 | — | IC50 | > | 1000.0 | nM | - |