Assay Detail
Functional
CHEMBL3292795
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Agonist activity at human beta2 receptor in BEAS-2B cells assessed as cAMP accumulation by radioimmunoassay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.96 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290999 | — | — | 1 | 9.40 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.30 |
| CHEMBL3290998 | — | — | 1 | 9.10 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 8.60 |
| CHEMBL3290997 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290999 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL3290998 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL3290997 | — | EC50 | = | 3.981 | nM | 8.40 |