Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL3290997

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(CO)c3)cc2)cc1-c1ccccc1

Basic Information

ChEMBL ID CHEMBL3290997
Phase Preclinical
Structure Type MOL
InChI Key CJOMMFVMZGNTNI-LJAQVGFWSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

484.6
MW (Da)
5.17
ALogP
6
HBA
5
HBD
94.0
PSA (Ų)
0.19
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H32N2O4
MW 484.60
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -0.14

Activity Summary

EC50 3 meas. best 9.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.3 8.85 0.5 2
Beta-2 adrenergic receptor
CHEMBL5414
EC50 8.7 8.7 2.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24813741 10.1016/j.bmcl.2014.04.069 Beta-2 adrenergic receptor 5
24813741 10.1016/j.bmcl.2014.04.069 Unchecked 2
24813741 10.1016/j.bmcl.2014.04.069 Beta-1 adrenergic receptor 1
24813741 10.1016/j.bmcl.2014.04.069 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine