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Assay Detail

CHEMBL3294076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiparasitic activity against Trypanosoma cruzi Tulahen LacZ/C4 amastigotes after 4 days by beta-galactosidase reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups.
Liu ZY, Wenzler T, Brun R, Zhu X, Boykin DW.
Eur J Med Chem (2014) 83 : 167 -173
PubMed 24956553 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.64 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1275764 1 7.00
CHEMBL3288913 1 6.70
CHEMBL3288925 1 6.22
CHEMBL3288915 1 5.82
CHEMBL3288922 1 5.80
CHEMBL110 BENZNIDAZOLE 4.0 1 5.73
CHEMBL3288919 1 5.64
CHEMBL3288921 1 5.64
CHEMBL3288923 1 5.51
CHEMBL3288924 1 5.39
CHEMBL3288920 1 5.25
CHEMBL3288927 1 5.21
CHEMBL55 PENTAMIDINE 4.0 1 5.15
CHEMBL3288914 1 4.80
CHEMBL3288926 1 4.75
CHEMBL3288917 1 -
CHEMBL3288918 1 -
CHEMBL3288916 1 -
CHEMBL267345 AMPHOTERICIN B 4.0 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1275764 IC50 = 100.0 nM 7.00
CHEMBL3288913 IC50 = 200.0 nM 6.70
CHEMBL3288925 IC50 = 600.0 nM 6.22
CHEMBL3288915 IC50 = 1500.0 nM 5.82
CHEMBL3288922 IC50 = 1600.0 nM 5.80
CHEMBL110 BENZNIDAZOLE IC50 = 1870.0 nM 5.73
CHEMBL3288919 IC50 = 2300.0 nM 5.64
CHEMBL3288921 IC50 = 2300.0 nM 5.64
CHEMBL3288923 IC50 = 3100.0 nM 5.51
CHEMBL3288924 IC50 = 4100.0 nM 5.39
CHEMBL3288920 IC50 = 5600.0 nM 5.25
CHEMBL3288927 IC50 = 6100.0 nM 5.21
CHEMBL55 PENTAMIDINE IC50 = 7100.0 nM 5.15
CHEMBL3288914 IC50 = 16000.0 nM 4.80
CHEMBL3288926 IC50 = 18000.0 nM 4.75
CHEMBL3288917 IC50 > 108000.0 nM -
CHEMBL3288918 IC50 > 122000.0 nM -
CHEMBL3288916 IC50 > 110000.0 nM -
CHEMBL267345 AMPHOTERICIN B IC50 - -
CHEMBL76 CHLOROQUINE IC50 - -