Assay Detail
Functional
CHEMBL3296163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HL60 cells assessed as inhibition of proliferation after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.73 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3290761 | — | — | 1 | 6.22 |
| CHEMBL3290763 | — | — | 1 | 6.16 |
| CHEMBL3290760 | — | — | 1 | 5.77 |
| CHEMBL3290762 | — | — | 1 | 5.70 |
| CHEMBL3290759 | — | — | 1 | 5.29 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | 4.0 | 1 | 5.24 |
| CHEMBL351769 | ARSANILIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3290761 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3290763 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3290760 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3290762 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3290759 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL351769 | ARSANILIC ACID | IC50 | > | 10000.0 | nM | - |