Assay Detail
Binding
CHEMBL3299342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.50 | 7.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3297892 | — | — | 1 | 7.79 |
| CHEMBL3298000 | — | — | 1 | 7.66 |
| CHEMBL3297898 | — | — | 1 | 7.64 |
| CHEMBL3297999 | — | — | 1 | 7.64 |
| CHEMBL3297899 | — | — | 1 | 7.57 |
| CHEMBL3297896 | — | — | 1 | 7.55 |
| CHEMBL3297900 | — | — | 1 | 7.52 |
| CHEMBL3297998 | — | — | 1 | 7.25 |
| CHEMBL3297897 | — | — | 1 | 7.20 |
| CHEMBL3297893 | — | — | 1 | 7.18 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL3297895 | — | — | 1 | - |
| CHEMBL3297894 | — | — | 1 | - |
| CHEMBL3297891 | — | — | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL3297816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3297892 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL3298000 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL3297898 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL3297999 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL3297899 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL3297896 | — | IC50 | = | 28.3 | nM | 7.55 |
| CHEMBL3297900 | — | IC50 | = | 29.9 | nM | 7.52 |
| CHEMBL3297998 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL3297897 | — | IC50 | = | 63.5 | nM | 7.20 |
| CHEMBL3297893 | — | IC50 | = | 66.1 | nM | 7.18 |
| CHEMBL553 | ERLOTINIB | IC50 | - | — | - | |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - | |
| CHEMBL276711 | SEMAXANIB | IC50 | - | — | - | |
| CHEMBL3297895 | — | IC50 | - | — | - | |
| CHEMBL3297894 | — | IC50 | - | — | - | |
| CHEMBL3297891 | — | IC50 | - | — | - | |
| CHEMBL535 | SUNITINIB | IC50 | = | 83.1 | nM | - |
| CHEMBL3297816 | — | IC50 | - | — | - |