Compound Detail
CHEMBL3297897
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3297897 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFTLZKDAWSMUNG-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
269.3
MW (Da)
3.59
ALogP
5
HBA
1
HBD
60.2
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.38 | 7.38 | 42.2 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.37 | 7.37 | 43.1 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.2 | 7.2 | 63.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 42.2 | nM | 7.38 | Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assay | 24890652 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 43.1 | nM | 7.37 | Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assay | 24890652 |
| Platelet-derived growth factor receptor beta | IC50 | = | 63.5 | nM | 7.2 | Inhibition of PDGFRbeta in human SH-SY5Y cells by phosphotyrosine ELISA assay | 24890652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24890652 | 10.1016/j.bmc.2014.04.049 | A-431 | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Chorioallantoic membrane | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Tubulin | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Vascular endothelial growth factor receptor 2 | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Epidermal growth factor receptor | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Platelet-derived growth factor receptor beta | 1 |
Data from ChEMBL 36 via Core Engine