Compound Detail
CHEMBL3297816
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Basic Information
| ChEMBL ID | CHEMBL3297816 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HTNOBSCJRZGDSX-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
239.3
MW (Da)
3.58
ALogP
4
HBA
1
HBD
51.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| A-431 CHEMBL614069 | IC50 | 7.32 | 7.32 | 48.2 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.3 | 7.3 | 50.3 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.95 | 6.95 | 113.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| A-431 | IC50 | = | 48.2 | nM | 7.32 | Cytotoxicity against human A431 cells by SRB assay | 24890652 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 50.3 | nM | 7.3 | Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assay | 24890652 |
| Epidermal growth factor receptor | IC50 | = | 113.2 | nM | 6.95 | Inhibition of EGFR in human A431 cells by phosphotyrosine ELISA assay | 24890652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24890652 | 10.1016/j.bmc.2014.04.049 | Platelet-derived growth factor receptor beta | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Chorioallantoic membrane | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | A-431 | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Vascular endothelial growth factor receptor 2 | 1 |
| 24890652 | 10.1016/j.bmc.2014.04.049 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine