Assay Detail
Functional
CHEMBL3299343
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Cytotoxicity against human A431 cells by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.46 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.87 |
| CHEMBL3297894 | — | — | 1 | 7.75 |
| CHEMBL3297898 | — | — | 1 | 7.68 |
| CHEMBL3297892 | — | — | 1 | 7.65 |
| CHEMBL3297900 | — | — | 1 | 7.37 |
| CHEMBL3297816 | — | — | 1 | 7.32 |
| CHEMBL3297891 | — | — | 1 | 7.31 |
| CHEMBL3297899 | — | — | 1 | 7.30 |
| CHEMBL3297896 | — | — | 1 | 7.30 |
| CHEMBL3297999 | — | — | 1 | 7.30 |
| CHEMBL3297893 | — | — | 1 | 7.26 |
| CHEMBL3298000 | — | — | 1 | 7.25 |
| CHEMBL3297895 | — | — | 1 | 7.22 |
| CHEMBL3297998 | — | — | 1 | 6.92 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | - |
| CHEMBL3297897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL3297894 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3297898 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL3297892 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL3297900 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL3297816 | — | IC50 | = | 48.2 | nM | 7.32 |
| CHEMBL3297891 | — | IC50 | = | 49.1 | nM | 7.31 |
| CHEMBL3297899 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL3297896 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3297999 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL3297893 | — | IC50 | = | 55.5 | nM | 7.26 |
| CHEMBL3298000 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL3297895 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3297998 | — | IC50 | = | 120.7 | nM | 6.92 |
| CHEMBL553 | ERLOTINIB | IC50 | - | — | - | |
| CHEMBL535 | SUNITINIB | IC50 | - | — | - | |
| CHEMBL276711 | SEMAXANIB | IC50 | - | — | - | |
| CHEMBL3297897 | — | IC50 | - | — | - |