Assay Detail
Binding
CHEMBL3367782
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Displacement of [3H]NMS from human muscarinic M1 receptor transfected in CHO cells after 120 mins by scintillation counting analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.98 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74300 | — | — | 1 | 5.71 |
| CHEMBL168815 | CEVIMELINE | 4.0 | 1 | 5.31 |
| CHEMBL387632 | — | — | 1 | 4.96 |
| CHEMBL390842 | — | — | 1 | 4.52 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.42 |
| CHEMBL3309715 | — | — | 1 | - |
| CHEMBL3359597 | — | — | 1 | - |
| CHEMBL3309717 | — | — | 1 | - |
| CHEMBL3309718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74300 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL168815 | CEVIMELINE | Ki | = | 4897.79 | nM | 5.31 |
| CHEMBL387632 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL390842 | — | Ki | = | 30199.52 | nM | 4.52 |
| CHEMBL14 | CARBACHOL | Ki | = | 38018.94 | nM | 4.42 |
| CHEMBL3309715 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3359597 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3309717 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3309718 | — | Ki | > | 100000.0 | nM | - |