Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3368508

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents.
Yang J, Liu Y, Xue C, Yu W, Zhang J, Qiao C.
Eur J Med Chem (2014) 86 : 235 -241
PubMed 25164762 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.87 5.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL549359 GLAUCOCALYXIN A 1 5.26
CHEMBL3330042 1 5.24
CHEMBL3330033 1 5.05
CHEMBL3356479 1 5.03
CHEMBL3330046 1 4.98
CHEMBL3330043 1 4.93
CHEMBL3330041 1 4.90
CHEMBL3330034 1 4.87
CHEMBL3330038 1 4.85
CHEMBL3330040 1 4.84
CHEMBL3330045 1 4.82
CHEMBL3330047 1 4.82
CHEMBL3330037 1 4.81
CHEMBL3330036 1 4.75
CHEMBL3330035 1 4.74
CHEMBL3330039 1 4.64
CHEMBL3330044 1 4.63
CHEMBL185 FLUOROURACIL 4.0 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL549359 GLAUCOCALYXIN A IC50 = 5520.0 nM 5.26
CHEMBL3330042 IC50 = 5700.0 nM 5.24
CHEMBL3330033 IC50 = 8920.0 nM 5.05
CHEMBL3356479 IC50 = 9350.0 nM 5.03
CHEMBL3330046 IC50 = 10540.0 nM 4.98
CHEMBL3330043 IC50 = 11710.0 nM 4.93
CHEMBL3330041 IC50 = 12530.0 nM 4.90
CHEMBL3330034 IC50 = 13480.0 nM 4.87
CHEMBL3330038 IC50 = 14070.0 nM 4.85
CHEMBL3330040 IC50 = 14560.0 nM 4.84
CHEMBL3330045 IC50 = 15280.0 nM 4.82
CHEMBL3330047 IC50 = 15080.0 nM 4.82
CHEMBL3330037 IC50 = 15610.0 nM 4.81
CHEMBL3330036 IC50 = 17770.0 nM 4.75
CHEMBL3330035 IC50 = 18130.0 nM 4.74
CHEMBL3330039 IC50 = 23030.0 nM 4.64
CHEMBL3330044 IC50 = 23240.0 nM 4.63
CHEMBL185 FLUOROURACIL IC50 = 27010.0 nM 4.57