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Compound Detail

CHEMBL3330046

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CC1(C)C(=O)CC[C@]2(C)[C@@H]1C[C@@H](O)[C@]13C(=O)C(CNc4ccc(C(=O)O)cc4)[C@H](CC[C@@H]21)[C@H]3O

Basic Information

ChEMBL ID CHEMBL3330046
Phase Preclinical
Structure Type MOL
InChI Key FOLKWDBFLWZFPJ-VGHSQITKSA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

469.6
MW (Da)
3.15
ALogP
6
HBA
4
HBD
123.9
PSA (Ų)
0.53
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H35NO6
MW 469.58
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 2.09

Activity Summary

IC50 7 meas. best 5.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
KB
CHEMBL398
IC50 5.21 5.21 6130.0 1
B16
CHEMBL381
IC50 5.17 5.17 6790.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.98 4.8033 10540.0 3
A549
CHEMBL392
IC50 4.93 4.93 11710.0 1
ADMET
CHEMBL612558
IC50 4.45 4.45 35390.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine