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Compound Detail

CHEMBL3356479

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CC1(C)C(=O)CC[C@]2(C)[C@@H]1C[C@@H](O)[C@]13C(=O)C(CNC4CCCCC4)[C@H](CC[C@@H]21)[C@H]3O

Basic Information

ChEMBL ID CHEMBL3356479
Phase Preclinical
Structure Type MOL
InChI Key XUAURMNBGCAXJQ-IMLJQXPSSA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

431.6
MW (Da)
3.26
ALogP
5
HBA
3
HBD
86.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H41NO4
MW 431.62
Aromatic Rings 0
Heavy Atoms 31
NP-Likeness 2.43

Activity Summary

IC50 7 meas. best 5.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
B16
CHEMBL381
IC50 5.25 5.25 5660.0 1
ADMET
CHEMBL612558
IC50 5.05 5.05 8950.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.03 4.8433 9350.0 3
A549
CHEMBL392
IC50 4.95 4.95 11120.0 1
KB
CHEMBL398
IC50 4.95 4.95 11280.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine