Assay Detail
Binding
CHEMBL3373058
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Displacement of [3H]TCP from rat brain NMDA receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
New N-aryl-N'-(3-(substituted)phenyl)-N'-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.00 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356813 | — | — | 1 | 7.74 |
| CHEMBL38936 | — | — | 1 | 7.50 |
| CHEMBL3356812 | — | — | 1 | 7.43 |
| CHEMBL3356798 | — | — | 1 | 7.40 |
| CHEMBL3356809 | — | — | 1 | 7.27 |
| CHEMBL3356829 | — | — | 1 | 7.11 |
| CHEMBL3356800 | — | — | 1 | 6.96 |
| CHEMBL3356817 | — | — | 1 | 6.82 |
| CHEMBL3356815 | — | — | 1 | 6.35 |
| CHEMBL3356803 | — | — | 1 | 6.27 |
| CHEMBL3356826 | — | — | 1 | 6.15 |
| CHEMBL3356799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356813 | — | Ki | = | 18.3 | nM | 7.74 |
| CHEMBL38936 | — | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL3356812 | — | Ki | = | 36.7 | nM | 7.43 |
| CHEMBL3356798 | — | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL3356809 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL3356829 | — | Ki | = | 78.4 | nM | 7.11 |
| CHEMBL3356800 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3356817 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL3356815 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL3356803 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL3356826 | — | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL3356799 | — | Ki | > | 1000.0 | nM | - |