Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3373784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of prolyl oligopeptidase (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prolyl endopeptidase (CHEMBL3202)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells.
Takahashi S, Yoshida A, Uesugi S, Hongo Y, Kimura K, Matsuoka K, Koshino H.
Bioorg Med Chem Lett (2014) 24 : 3373 -3376
PubMed 24948566 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.17 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL515528 1 5.90
CHEMBL2448554 1 5.85
CHEMBL3314375 1 5.46
CHEMBL3314370 1 4.94
CHEMBL3314372 1 4.83
CHEMBL3238007 1 4.82
CHEMBL3314373 1 4.82
CHEMBL3314374 1 4.75
CHEMBL3314368 1 -
CHEMBL3314369 1 -
CHEMBL3314371 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL515528 IC50 = 1250.0 nM 5.90
CHEMBL2448554 IC50 = 1400.0 nM 5.85
CHEMBL3314375 IC50 = 3500.0 nM 5.46
CHEMBL3314370 IC50 = 11500.0 nM 4.94
CHEMBL3314372 IC50 = 14900.0 nM 4.83
CHEMBL3238007 IC50 = 15200.0 nM 4.82
CHEMBL3314373 IC50 = 15100.0 nM 4.82
CHEMBL3314374 IC50 = 17700.0 nM 4.75
CHEMBL3314368 IC50 > 50000.0 nM -
CHEMBL3314369 IC50 > 50000.0 nM -
CHEMBL3314371 IC50 > 50000.0 nM -