Compound Detail
CHEMBL3314373
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CC(C)(C)[Si](C)(C)Oc1ccc(C2=C3OCOC3=C(c3ccc(O[Si](C)(C)C(C)(C)C)cc3)C(=O)C2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL3314373 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTRGLMUGDWSTTH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
564.8
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
| Prolyl endopeptidase CHEMBL3202 | IC50 | 4.82 | 4.82 | 15100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | IC50 | = | 2800.0 | nM | 5.55 | Cytotoxicity against human HL60 cells after 48 hrs by MTT assay | 24948566 |
| Prolyl endopeptidase | IC50 | = | 15100.0 | nM | 4.82 | Inhibition of prolyl oligopeptidase (unknown origin) | 24948566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24948566 | 10.1016/j.bmcl.2014.05.091 | NON-PROTEIN TARGET | 1 |
| 24948566 | 10.1016/j.bmcl.2014.05.091 | Prolyl endopeptidase | 1 |
Data from ChEMBL 36 via Core Engine