Assay Detail
Functional
CHEMBL3373785
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Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.20 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314373 | — | — | 1 | 5.55 |
| CHEMBL3314374 | — | — | 1 | 5.54 |
| CHEMBL3314375 | — | — | 1 | 5.38 |
| CHEMBL3314370 | — | — | 1 | 5.19 |
| CHEMBL3314368 | — | — | 1 | 4.84 |
| CHEMBL3314371 | — | — | 1 | 4.72 |
| CHEMBL3314372 | — | — | 1 | - |
| CHEMBL3314369 | — | — | 1 | - |
| CHEMBL3238007 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314373 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3314374 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3314375 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3314370 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3314368 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3314371 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL3314372 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3314369 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3238007 | — | IC50 | > | 20000.0 | nM | - |