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Assay Detail

CHEMBL3374067

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human DU145 cells after 48 to 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion.
Clarion L, Jacquard C, Sainte-Catherine O, Decoux M, Loiseau S, Rolland M, Lecouvey M, Hugnot JP, Volle JN, Virieux D, Pirat JL, Bakalara N.
J Med Chem (2014) 57 : 8293 -8306
PubMed 25211466 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.51 4.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3343647 1 4.51
CHEMBL3343407 1 -
CHEMBL3343408 1 -
CHEMBL3343409 1 -
CHEMBL3343410 1 -
CHEMBL3343411 1 -
CHEMBL3343412 1 -
CHEMBL3343413 1 -
CHEMBL3343414 1 -
CHEMBL3343415 1 -
CHEMBL3343641 1 -
CHEMBL3343642 1 -
CHEMBL3343643 1 -
CHEMBL3343644 1 -
CHEMBL3341777 1 -
CHEMBL3343645 1 -
CHEMBL3343646 1 -
CHEMBL3343416 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3343647 IC50 = 31160.0 nM 4.51
CHEMBL3343407 IC50 > 100000.0 nM -
CHEMBL3343408 IC50 > 100000.0 nM -
CHEMBL3343409 IC50 > 100000.0 nM -
CHEMBL3343410 IC50 > 100000.0 nM -
CHEMBL3343411 IC50 > 100000.0 nM -
CHEMBL3343412 IC50 > 100000.0 nM -
CHEMBL3343413 IC50 > 100000.0 nM -
CHEMBL3343414 IC50 > 100000.0 nM -
CHEMBL3343415 IC50 > 100000.0 nM -
CHEMBL3343641 IC50 > 100000.0 nM -
CHEMBL3343642 IC50 > 100000.0 nM -
CHEMBL3343643 IC50 > 100000.0 nM -
CHEMBL3343644 IC50 > 100000.0 nM -
CHEMBL3341777 IC50 > 100000.0 nM -
CHEMBL3343645 IC50 > 100000.0 nM -
CHEMBL3343646 IC50 > 100000.0 nM -
CHEMBL3343416 IC50 > 100000.0 nM -