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Compound Detail

CHEMBL3343408

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CC1(C)O[C@H]2[C@@H]([C@H]3COC(C)(C)O3)O[P@@](=O)(c3ccccc3)[C@@H](O)[C@H]2O1

Basic Information

ChEMBL ID CHEMBL3343408
Phase Preclinical
Structure Type MOL
InChI Key MAKXAOVRUMEYMV-DTNCKUBDSA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

384.4
MW (Da)
1.98
ALogP
7
HBA
1
HBD
83.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H25O7P
MW 384.37
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness 0.69

Activity Summary

IC50 7 meas. best 6.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A-431
CHEMBL614069
IC50 6.01 6.01 980.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.43 5.1633 3720.0 3
MDA-MB-231
CHEMBL400
IC50 5.22 5.22 6080.0 1
MDA-MB-435
CHEMBL614697
IC50 4.96 4.96 11020.0 1
SNB-75
CHEMBL614451
IC50 4.87 4.87 13410.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25211466 10.1021/jm500522y NON-PROTEIN TARGET 5
25211466 10.1021/jm500522y MDA-MB-435 1
25211466 10.1021/jm500522y A-431 1
25211466 10.1021/jm500522y MDA-MB-231 1
25211466 10.1021/jm500522y DU-145 1
25211466 10.1021/jm500522y C6 1
25211466 10.1021/jm500522y SNB-75 1

Data from ChEMBL 36 via Core Engine