Assay Detail
Functional
CHEMBL3376047
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Antiprotozoan activity against Trypanosoma cruzi Tulahuen C4 amastigotes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.19 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098604 | — | — | 1 | 6.07 |
| CHEMBL3098602 | — | — | 1 | 6.01 |
| CHEMBL3353926 | — | — | 1 | 5.68 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.67 |
| CHEMBL3353928 | — | — | 1 | 5.40 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.00 |
| CHEMBL3353927 | — | — | 1 | 4.72 |
| CHEMBL3353925 | — | — | 1 | 4.59 |
| CHEMBL3098695 | — | — | 1 | 4.48 |
| CHEMBL3098691 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098604 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL3098602 | — | IC50 | = | 972.0 | nM | 6.01 |
| CHEMBL3353926 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3353928 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3353927 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL3353925 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL3098695 | — | IC50 | = | 32950.0 | nM | 4.48 |
| CHEMBL3098691 | — | IC50 | = | 48350.0 | nM | 4.32 |