Assay Detail
Functional
CHEMBL3377827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Trypanocidal activity against intracellular amastigote form of Trypanosoma cruzi IRHOD/CO/2008/SN3 in african green monkey Vero cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.66 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355357 | — | — | 1 | 5.15 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.63 |
| CHEMBL195296 | SUGIOL | — | 1 | 4.61 |
| CHEMBL3355356 | — | — | 1 | 4.59 |
| CHEMBL3355358 | — | — | 1 | 4.57 |
| CHEMBL3355355 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355357 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL195296 | SUGIOL | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL3355356 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3355358 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL3355355 | — | IC50 | = | 41900.0 | nM | 4.38 |