Assay Detail
ADMET
CHEMBL3385972
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Inhibition of human recombinant CYP2D6 incubated for 5 mins by fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.11 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331469 | — | — | 1 | 8.00 |
| CHEMBL3331506 | — | — | 1 | 7.70 |
| CHEMBL3331504 | — | — | 1 | 6.89 |
| CHEMBL3331502 | — | — | 1 | 6.21 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 5.80 |
| CHEMBL3331508 | — | — | 1 | 5.73 |
| CHEMBL3331484 | — | — | 1 | 5.68 |
| CHEMBL3331503 | — | — | 1 | 5.63 |
| CHEMBL3331507 | — | — | 1 | 4.86 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331469 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3331506 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3331504 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3331502 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL3331508 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL3331484 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3331503 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL3331507 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 25100.0 | nM | 4.60 |