Assay Detail
Binding
CHEMBL3390819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of MRP1 mediated drug efflux in doxorubicin-resistant human H69 cells assessed as accumulation of calcein AM incubated for 15 mins prior to calcein AM addition measured after 30 mins by fluorescence analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.08 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342124 | — | — | 1 | 5.96 |
| CHEMBL3342123 | — | — | 1 | 5.41 |
| CHEMBL3342117 | — | — | 1 | 5.28 |
| CHEMBL3342116 | — | — | 1 | 5.28 |
| CHEMBL3344541 | — | — | 1 | 5.18 |
| CHEMBL3342125 | — | — | 1 | 5.16 |
| CHEMBL1506885 | — | — | 1 | 5.01 |
| CHEMBL3344543 | — | — | 1 | 4.92 |
| CHEMBL15177 | MK-571 | — | 1 | 4.91 |
| CHEMBL3342118 | — | — | 1 | 4.91 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.56 |
| CHEMBL3342110 | — | — | 1 | 4.38 |
| CHEMBL3344542 | — | — | 1 | - |
| CHEMBL3342111 | — | — | 1 | - |
| CHEMBL3342112 | — | — | 1 | - |
| CHEMBL3342113 | — | — | 1 | - |
| CHEMBL3342115 | — | — | 1 | - |
| CHEMBL3342119 | — | — | 1 | - |
| CHEMBL3342120 | — | — | 1 | - |
| CHEMBL3342121 | — | — | 1 | - |
| CHEMBL3342122 | — | — | 1 | - |
| CHEMBL3342135 | — | — | 1 | - |
| CHEMBL3342126 | — | — | 1 | - |
| CHEMBL3342127 | — | — | 1 | - |
| CHEMBL3342128 | — | — | 1 | - |
| CHEMBL3342129 | — | — | 1 | - |
| CHEMBL3342134 | — | — | 1 | - |
| CHEMBL3342133 | — | — | 1 | - |
| CHEMBL3342131 | — | — | 1 | - |
| CHEMBL3342130 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342124 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3342123 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3342117 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3342116 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3344541 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3342125 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1506885 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3344543 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL15177 | MK-571 | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3342118 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL3342110 | — | EC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL3344542 | — | EC50 | - | — | - | |
| CHEMBL3342111 | — | EC50 | - | — | - | |
| CHEMBL3342112 | — | EC50 | - | — | - | |
| CHEMBL3342113 | — | EC50 | - | — | - | |
| CHEMBL3342115 | — | EC50 | - | — | - | |
| CHEMBL3342119 | — | EC50 | - | — | - | |
| CHEMBL3342120 | — | EC50 | - | — | - | |
| CHEMBL3342121 | — | EC50 | - | — | - | |
| CHEMBL3342122 | — | EC50 | - | — | - | |
| CHEMBL3342135 | — | EC50 | - | — | - | |
| CHEMBL3342126 | — | EC50 | - | — | - | |
| CHEMBL3342127 | — | EC50 | - | — | - | |
| CHEMBL3342128 | — | EC50 | - | — | - | |
| CHEMBL3342129 | — | EC50 | - | — | - | |
| CHEMBL3342134 | — | EC50 | - | — | - | |
| CHEMBL3342133 | — | EC50 | - | — | - | |
| CHEMBL3342131 | — | EC50 | - | — | - | |
| CHEMBL3342130 | — | EC50 | - | — | - |