Assay Detail
Binding
CHEMBL3391358
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Displacement of [3H]CGP-39653 from NMDA receptor in rat brain cortical membranes
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A highly selective agonist for the metabotropic glutamate receptor mGluR2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 4.66 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.70 |
| CHEMBL3347672 | — | — | 2 | 4.73 |
| CHEMBL3347671 | — | — | 2 | 4.14 |
| CHEMBL3347670 | — | — | 2 | 4.11 |
| CHEMBL334842 | — | — | 1 | - |
| CHEMBL131922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3347672 | — | Ki | = | 18620.87 | nM | 4.73 |
| CHEMBL3347672 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL3347671 | — | Ki | = | 72443.6 | nM | 4.14 |
| CHEMBL3347671 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL3347670 | — | Ki | = | 77624.71 | nM | 4.11 |
| CHEMBL3347670 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL334842 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL131922 | — | Ki | > | 100000.0 | nM | - |