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Assay Detail

CHEMBL3413261

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Functional
Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells assessed as parasite growth inhibition after 96 hrs by colorimetric analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Papadopoulou MV, Bloomer WD, Lepesheva GI, Rosenzweig HS, Kaiser M, Aguilera-Venegas B, Wilkinson SR, Chatelain E, Ioset JR.
J Med Chem (2015) 58 : 1307 -1319
PubMed 25580906 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.04 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3410636 1 7.48
CHEMBL3410622 1 7.35
CHEMBL3407532 1 6.99
CHEMBL3410634 1 6.99
CHEMBL3410620 1 6.86
CHEMBL3410628 1 6.73
CHEMBL3410638 1 6.47
CHEMBL3410623 1 6.34
CHEMBL3410625 1 6.26
CHEMBL3410626 1 6.26
CHEMBL3410633 1 6.15
CHEMBL3410635 1 5.93
CHEMBL3410627 1 5.92
CHEMBL110 BENZNIDAZOLE 4.0 1 5.66
CHEMBL3410631 1 5.48
CHEMBL3410624 1 5.40
CHEMBL3410637 1 5.24
CHEMBL106 FLUCONAZOLE 4.0 1 5.00
CHEMBL3410630 1 4.85
CHEMBL3410621 1 4.78
CHEMBL3410629 1 4.64
CHEMBL3410632 1 -
CHEMBL3410639 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3410636 IC50 = 33.0 nM 7.48
CHEMBL3410622 IC50 = 45.0 nM 7.35
CHEMBL3407532 IC50 = 102.0 nM 6.99
CHEMBL3410634 IC50 = 102.0 nM 6.99
CHEMBL3410620 IC50 = 138.0 nM 6.86
CHEMBL3410628 IC50 = 188.0 nM 6.73
CHEMBL3410638 IC50 = 339.0 nM 6.47
CHEMBL3410623 IC50 = 459.0 nM 6.34
CHEMBL3410625 IC50 = 552.0 nM 6.26
CHEMBL3410626 IC50 = 554.0 nM 6.26
CHEMBL3410633 IC50 = 706.0 nM 6.15
CHEMBL3410635 IC50 = 1174.0 nM 5.93
CHEMBL3410627 IC50 = 1194.0 nM 5.92
CHEMBL110 BENZNIDAZOLE IC50 = 2180.0 nM 5.66
CHEMBL3410631 IC50 = 3290.0 nM 5.48
CHEMBL3410624 IC50 = 3986.0 nM 5.40
CHEMBL3410637 IC50 = 5786.0 nM 5.24
CHEMBL106 FLUCONAZOLE IC50 = 9967.0 nM 5.00
CHEMBL3410630 IC50 = 14229.0 nM 4.85
CHEMBL3410621 IC50 = 16580.0 nM 4.78
CHEMBL3410629 IC50 = 22775.0 nM 4.64
CHEMBL3410632 IC50 = 157200.0 nM -
CHEMBL3410639 IC50 = 187500.0 nM -