Assay Detail
Binding
CHEMBL3419225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated peptide measured after 30 mins by AlphaScreen assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain adjacent to zinc finger domain protein 2B (CHEMBL1741220) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.72 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4296718 | — | — | 1 | 6.75 |
| CHEMBL3415184 | — | — | 1 | 6.11 |
| CHEMBL3415185 | — | — | 1 | 6.10 |
| CHEMBL3415182 | — | — | 1 | 5.97 |
| CHEMBL3415186 | — | — | 1 | 5.61 |
| CHEMBL3415177 | — | — | 1 | 5.36 |
| CHEMBL3415179 | — | — | 1 | 5.28 |
| CHEMBL3415176 | — | — | 1 | 4.58 |
| CHEMBL3415178 | — | — | 1 | - |
| CHEMBL3415180 | — | — | 1 | - |
| CHEMBL3415181 | — | — | 1 | - |
| CHEMBL3415183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4296718 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3415184 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3415185 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3415182 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3415186 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL3415177 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3415179 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL3415176 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3415178 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3415180 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3415181 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3415183 | — | IC50 | > | 50000.0 | nM | - |