Compound Detail
CHEMBL3415185
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Basic Information
| ChEMBL ID | CHEMBL3415185 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SLVMDFGFHWCYDS-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
362.4
MW (Da)
2.37
ALogP
8
HBA
0
HBD
90.1
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.35
EC50 1 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A CHEMBL3108642 | IC50 | 6.35 | 6.35 | 450.0 | 1 |
| Bromodomain adjacent to zinc finger domain protein 2B CHEMBL1741220 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 5.16 | 5.16 | 6941.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A | IC50 | = | 450.0 | nM | 6.35 | Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | 25719566 |
| Bromodomain adjacent to zinc finger domain protein 2B | IC50 | = | 790.0 | nM | 6.1 | Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins wit... | 25719566 |
| Metabotropic glutamate receptor 4 | EC50 | = | 6941.0 | nM | 5.16 | Metabotropic Glutamate Receptor Activity: The disclosed compounds and compositio... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25719566 | 10.1021/jm501963e | Bromodomain adjacent to zinc finger domain protein 2A | 1 |
| 25719566 | 10.1021/jm501963e | Bromodomain adjacent to zinc finger domain protein 2B | 1 |
Data from ChEMBL 36 via Core Engine