Compound Detail
CHEMBL3415186
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Basic Information
| ChEMBL ID | CHEMBL3415186 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GTOATASLSLQVCO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
364.4
MW (Da)
2.26
ALogP
9
HBA
0
HBD
109.5
PSA (Ų)
0.40
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A CHEMBL3108642 | IC50 | 5.86 | 5.86 | 1380.0 | 1 |
| Bromodomain adjacent to zinc finger domain protein 2B CHEMBL1741220 | IC50 | 5.61 | 5.61 | 2450.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain adjacent to zinc finger domain protein 2A | IC50 | = | 1380.0 | nM | 5.86 | Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay | 25719566 |
| Bromodomain adjacent to zinc finger domain protein 2B | IC50 | = | 2450.0 | nM | 5.61 | Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins wit... | 25719566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25719566 | 10.1021/jm501963e | Bromodomain adjacent to zinc finger domain protein 2A | 1 |
| 25719566 | 10.1021/jm501963e | Bromodomain adjacent to zinc finger domain protein 2B | 1 |
Data from ChEMBL 36 via Core Engine