Assay Detail
Functional
CHEMBL3419299
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Antifilarial activity against Brugia malayi adult worm assessed as reduction in motility after 5 days by MTT dye reduction assay
24
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Brugia malayi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-oxycoumarin derivatives as a new class of antifilarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 12 | - | - |
| IC50 | 12 | 6.36 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416681 | — | — | 2 | 7.85 |
| CHEMBL3416682 | — | — | 2 | 7.03 |
| CHEMBL3416676 | — | — | 2 | 6.44 |
| CHEMBL3416680 | — | — | 2 | 6.16 |
| CHEMBL3416675 | — | — | 2 | 6.06 |
| CHEMBL3416684 | — | — | 2 | 5.86 |
| CHEMBL3416677 | — | — | 2 | 5.76 |
| CHEMBL6067487 | IVERMECTIN | 4.0 | 2 | 5.75 |
| CHEMBL3416678 | — | — | 2 | - |
| CHEMBL3416679 | — | — | 2 | - |
| CHEMBL3416683 | — | — | 2 | - |
| CHEMBL684 | DIETHYLCARBAMAZINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416681 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3416682 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3416676 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3416680 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3416675 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3416684 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3416677 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL6067487 | IVERMECTIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3416676 | — | MIC | = | 2500.0 | nM | - |
| CHEMBL3416677 | — | MIC | = | 5000.0 | nM | - |
| CHEMBL3416678 | — | MIC | - | — | - | |
| CHEMBL3416679 | — | MIC | - | — | - | |
| CHEMBL3416680 | — | MIC | = | 2500.0 | nM | - |
| CHEMBL3416681 | — | MIC | = | 1250.0 | nM | - |
| CHEMBL3416682 | — | MIC | = | 310.0 | nM | - |
| CHEMBL3416683 | — | MIC | - | — | - | |
| CHEMBL3416684 | — | MIC | = | 5000.0 | nM | - |
| CHEMBL6067487 | IVERMECTIN | MIC | = | 8900.0 | nM | - |
| CHEMBL684 | DIETHYLCARBAMAZINE | MIC | - | — | - | |
| CHEMBL3416678 | — | IC50 | - | — | - | |
| CHEMBL3416679 | — | IC50 | - | — | - | |
| CHEMBL3416683 | — | IC50 | - | — | - | |
| CHEMBL3416675 | — | MIC | = | 5000.0 | nM | - |
| CHEMBL684 | DIETHYLCARBAMAZINE | IC50 | - | — | - |