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Assay Detail

CHEMBL3420262

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Functional
Anti-trypanosomal activity against Trypanosoma cruzi Bug 2149 cl10 epimastigote forms assessed as inhibition of parasite growth after 72 hrs by microplate reader based assay
ChEMBL ↗
48
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Designing and exploring active N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients.
Palace-Berl F, Pasqualoto KF, Jorge SD, Zingales B, Zorzi RR, Silva MN, Ferreira AK, de Azevedo RA, Teixeira SF, Tavares LC.
Eur J Med Chem (2015) 96 : 330 -339
PubMed 25899337 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.94 5.74
log1/IC50 24 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3415957 — — 2 5.74
CHEMBL3415956 — — 2 5.38
CHEMBL3260878 — — 2 5.37
CHEMBL2413121 — — 2 5.36
CHEMBL290960 NIFURTIMOX 4.0 2 5.13
CHEMBL3415955 — — 2 5.04
CHEMBL3260877 — — 2 5.01
CHEMBL3260876 — — 2 5.01
CHEMBL1733454 — — 2 4.91
CHEMBL3415958 — — 2 4.91
CHEMBL3415954 — — 2 4.91
CHEMBL3415953 — — 2 4.91
CHEMBL1706384 — — 2 4.89
CHEMBL3260871 — — 2 4.86
CHEMBL472882 — — 2 4.85
CHEMBL1981612 — — 2 4.84
CHEMBL479592 — — 2 4.84
CHEMBL3196547 — — 2 4.84
CHEMBL1565322 NIHYDRAZONE 2.0 2 4.80
CHEMBL442989 — — 2 4.61
CHEMBL2413120 — — 2 4.60
CHEMBL110 BENZNIDAZOLE 4.0 2 4.51
CHEMBL521258 — — 2 4.33
CHEMBL244888 NIFUROXAZIDE 3.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3415957 — IC50 = 1810.0 nM 5.74
CHEMBL3415956 — IC50 = 4220.0 nM 5.38
CHEMBL3260878 — IC50 = 4250.0 nM 5.37
CHEMBL2413121 — IC50 = 4410.0 nM 5.36
CHEMBL290960 NIFURTIMOX IC50 = 7320.0 nM 5.13
CHEMBL3415955 — IC50 = 9040.0 nM 5.04
CHEMBL3260877 — IC50 = 9720.0 nM 5.01
CHEMBL3260876 — IC50 = 9800.0 nM 5.01
CHEMBL1733454 — IC50 = 12200.0 nM 4.91
CHEMBL3415958 — IC50 = 12190.0 nM 4.91
CHEMBL3415953 — IC50 = 12250.0 nM 4.91
CHEMBL3415954 — IC50 = 12260.0 nM 4.91
CHEMBL1706384 — IC50 = 12770.0 nM 4.89
CHEMBL3260871 — IC50 = 13670.0 nM 4.86
CHEMBL472882 — IC50 = 14250.0 nM 4.85
CHEMBL3196547 — IC50 = 14550.0 nM 4.84
CHEMBL479592 — IC50 = 14450.0 nM 4.84
CHEMBL1981612 — IC50 = 14400.0 nM 4.84
CHEMBL1565322 NIHYDRAZONE IC50 = 15850.0 nM 4.80
CHEMBL442989 — IC50 = 24810.0 nM 4.61
CHEMBL2413120 — IC50 = 25260.0 nM 4.60
CHEMBL110 BENZNIDAZOLE IC50 = 30630.0 nM 4.51
CHEMBL521258 — IC50 = 47290.0 nM 4.33
CHEMBL1733454 — log1/IC50 = 4.91 — -
CHEMBL1981612 — log1/IC50 = 4.84 — -
CHEMBL479592 — log1/IC50 = 4.84 — -
CHEMBL2413120 — log1/IC50 = 4.6 — -
CHEMBL3415954 — log1/IC50 = 4.91 — -
CHEMBL442989 — log1/IC50 = 4.61 — -
CHEMBL1706384 — log1/IC50 = 4.89 — -
CHEMBL472882 — log1/IC50 = 4.85 — -
CHEMBL3415953 — log1/IC50 = 4.91 — -
CHEMBL3196547 — log1/IC50 = 4.84 — -
CHEMBL1565322 NIHYDRAZONE log1/IC50 = 4.8 — -
CHEMBL244888 NIFUROXAZIDE IC50 = 300000.0 nM -
CHEMBL3415955 — log1/IC50 = 5.04 — -
CHEMBL244888 NIFUROXAZIDE log1/IC50 = 3.52 — -
CHEMBL290960 NIFURTIMOX log1/IC50 = 5.14 — -
CHEMBL110 BENZNIDAZOLE log1/IC50 = 4.51 — -
CHEMBL3415958 — log1/IC50 = 4.91 — -
CHEMBL3415957 — log1/IC50 = 5.74 — -
CHEMBL3260878 — log1/IC50 = 5.37 — -
CHEMBL3415956 — log1/IC50 = 5.37 — -
CHEMBL3260877 — log1/IC50 = 5.01 — -
CHEMBL3260871 — log1/IC50 = 4.86 — -
CHEMBL2413121 — log1/IC50 = 5.36 — -
CHEMBL521258 — log1/IC50 = 4.33 — -
CHEMBL3260876 — log1/IC50 = 5.01 — -