Assay Detail
Binding
CHEMBL3595951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-MK-801 from rat cortical membranes NMDA receptor by beta counting analysis in presence of 30 uM spermine
79
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 79 | 4.64 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594017 | — | — | 1 | 5.88 |
| CHEMBL3594016 | — | — | 1 | 5.67 |
| CHEMBL181480 | — | — | 1 | 5.26 |
| CHEMBL269032 | — | — | 1 | 5.26 |
| CHEMBL3594011 | — | — | 1 | 5.25 |
| CHEMBL229102 | — | — | 1 | 5.21 |
| CHEMBL249456 | — | — | 1 | 5.17 |
| CHEMBL3594195 | — | — | 1 | 5.17 |
| CHEMBL24057 | FURAMIDINE | -1.0 | 1 | 5.13 |
| CHEMBL3594196 | — | — | 1 | 4.93 |
| CHEMBL3594014 | — | — | 1 | 4.90 |
| CHEMBL1232046 | — | — | 1 | 4.87 |
| CHEMBL3594080 | — | — | 1 | 4.86 |
| CHEMBL165542 | — | — | 1 | 4.75 |
| CHEMBL185172 | — | — | 1 | 4.74 |
| CHEMBL3594012 | — | — | 1 | 4.68 |
| CHEMBL137195 | — | — | 1 | 4.62 |
| CHEMBL284933 | — | — | 1 | 4.62 |
| CHEMBL3594009 | — | — | 1 | 4.62 |
| CHEMBL3594081 | — | — | 1 | 4.61 |
| CHEMBL3593840 | — | — | 1 | 4.60 |
| CHEMBL3594082 | — | — | 1 | 4.59 |
| CHEMBL365916 | — | — | 1 | 4.59 |
| CHEMBL1080776 | — | — | 1 | 4.56 |
| CHEMBL3594018 | — | — | 1 | 4.54 |
| CHEMBL3594008 | — | — | 1 | 4.54 |
| CHEMBL3594197 | — | — | 1 | 4.52 |
| CHEMBL279660 | — | — | 1 | 4.51 |
| CHEMBL3594083 | — | — | 1 | 4.51 |
| CHEMBL424711 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594017 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL3594016 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL269032 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL181480 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL3594011 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL229102 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL249456 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3594195 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL24057 | FURAMIDINE | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL3594196 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3594014 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1232046 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL3594080 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL165542 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL185172 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL3594012 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL137195 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL284933 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3594009 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL3594081 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL3593840 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3594082 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL365916 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL1080776 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL3594008 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3594018 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL3594197 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL279660 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL3594083 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL424711 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL9391 | — | IC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL3594013 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL3594010 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL183814 | BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL1170755 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL1169964 | — | IC50 | = | 50700.0 | nM | 4.29 |
| CHEMBL142952 | — | IC50 | = | 52900.0 | nM | 4.28 |
| CHEMBL1170985 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL1081887 | — | IC50 | = | 62600.0 | nM | 4.20 |
| CHEMBL9126 | — | IC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL9531 | — | IC50 | = | 70900.0 | nM | 4.15 |
| CHEMBL1852874 | — | IC50 | = | 74900.0 | nM | 4.13 |
| CHEMBL283745 | — | IC50 | = | 84200.0 | nM | 4.08 |
| CHEMBL1170548 | — | IC50 | = | 85300.0 | nM | 4.07 |
| CHEMBL88596 | — | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL9185 | — | IC50 | = | 92200.0 | nM | 4.04 |
| CHEMBL586743 | — | IC50 | = | 466000.0 | nM | - |
| CHEMBL8892 | — | IC50 | = | 106000.0 | nM | - |
| CHEMBL535664 | — | IC50 | = | 159000.0 | nM | - |
| CHEMBL535205 | — | IC50 | = | 139000.0 | nM | - |