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Assay Detail

CHEMBL3606212

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C4 expressing LacZ gene infected in rat L6 cells after 96 hrs by inverted microscope analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.
Prati F, Bergamini C, Molina MT, Falchi F, Cavalli A, Kaiser M, Brun R, Fato R, Bolognesi ML.
J Med Chem (2015) 58 : 6422 -6434
PubMed 26237241 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.46 5.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3604091 1 5.79
CHEMBL110 BENZNIDAZOLE 4.0 1 5.77
CHEMBL3604079 1 5.41
CHEMBL3604087 1 5.39
CHEMBL3604097 1 5.38
CHEMBL3604085 1 5.38
CHEMBL3604096 1 5.13
CHEMBL3604093 1 -
CHEMBL3604080 1 -
CHEMBL3604092 1 -
CHEMBL3604090 1 -
CHEMBL3604089 1 -
CHEMBL3604088 1 -
CHEMBL3604086 1 -
CHEMBL3604084 1 -
CHEMBL3604083 1 -
CHEMBL3604082 1 -
CHEMBL3604081 1 -
CHEMBL3604094 1 -
CHEMBL3604105 1 -
CHEMBL3604104 1 -
CHEMBL3604103 1 -
CHEMBL3604102 1 -
CHEMBL3604101 1 -
CHEMBL3604100 1 -
CHEMBL3604099 1 -
CHEMBL3604098 1 -
CHEMBL3604191 1 -
CHEMBL3604095 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3604091 IC50 = 1620.0 nM 5.79
CHEMBL110 BENZNIDAZOLE IC50 = 1700.0 nM 5.77
CHEMBL3604079 IC50 = 3910.0 nM 5.41
CHEMBL3604087 IC50 = 4060.0 nM 5.39
CHEMBL3604097 IC50 = 4170.0 nM 5.38
CHEMBL3604085 IC50 = 4170.0 nM 5.38
CHEMBL3604096 IC50 = 7390.0 nM 5.13
CHEMBL3604093 IC50 - -
CHEMBL3604080 IC50 - -
CHEMBL3604092 IC50 - -
CHEMBL3604090 IC50 - -
CHEMBL3604089 IC50 - -
CHEMBL3604088 IC50 - -
CHEMBL3604086 IC50 - -
CHEMBL3604084 IC50 - -
CHEMBL3604083 IC50 - -
CHEMBL3604082 IC50 - -
CHEMBL3604081 IC50 - -
CHEMBL3604094 IC50 - -
CHEMBL3604105 IC50 - -
CHEMBL3604104 IC50 - -
CHEMBL3604103 IC50 - -
CHEMBL3604102 IC50 - -
CHEMBL3604101 IC50 - -
CHEMBL3604100 IC50 - -
CHEMBL3604099 IC50 - -
CHEMBL3604098 IC50 - -
CHEMBL3604191 IC50 - -
CHEMBL3604095 IC50 - -