Assay Detail
Binding
CHEMBL3637632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DPDPE from delta opioid receptor in rat brain membrane after 120 mins by scintillation counting
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.28 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267495 | NALFURAFINE | 4.0 | 1 | 9.43 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.70 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.60 |
| CHEMBL3634516 | — | — | 1 | 7.24 |
| CHEMBL3634515 | — | — | 2 | 7.10 |
| CHEMBL3634398 | — | — | 1 | 6.89 |
| CHEMBL3299005 | — | — | 1 | 6.30 |
| CHEMBL3634395 | — | — | 1 | 6.28 |
| CHEMBL3634397 | — | — | 1 | 5.99 |
| CHEMBL58033 | (-)-U-50488 | — | 1 | - |
| CHEMBL603370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267495 | NALFURAFINE | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL70 | MORPHINE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL80 | NALOXONE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL3634516 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3634515 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL3634398 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL3299005 | — | Ki | = | 497.0 | nM | 6.30 |
| CHEMBL3634515 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL3634395 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL3634397 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL58033 | (-)-U-50488 | Ki | - | — | - | |
| CHEMBL603370 | — | Ki | - | — | - |