Assay Detail
Binding
CHEMBL3705053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Radioactivity Assay: The determination of IC50 values was performed with enzyme isolated from human placenta (Luu-The, V. et al., J. Steroid Biochem. Mol. Biol., 55:581-587 (1995): Sam, K. M. et al., Drug Des Discov., 15:157-180 (1997)). The radioactivity is determined by means of scintillation measurement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3645224 | — | — | 1 | 8.15 |
| CHEMBL3645221 | — | — | 1 | 8.00 |
| CHEMBL3645217 | — | — | 1 | 7.70 |
| CHEMBL1650657 | — | — | 1 | 7.70 |
| CHEMBL1650658 | — | — | 1 | 7.64 |
| CHEMBL3645225 | — | — | 1 | 7.52 |
| CHEMBL1650647 | — | — | 1 | 7.41 |
| CHEMBL1650655 | — | — | 1 | 7.40 |
| CHEMBL3645219 | — | — | 1 | 7.30 |
| CHEMBL3645223 | — | — | 1 | 7.30 |
| CHEMBL3645226 | — | — | 1 | 7.22 |
| CHEMBL3645215 | — | — | 1 | 7.16 |
| CHEMBL3645218 | — | — | 1 | 7.05 |
| CHEMBL3645222 | — | — | 1 | 6.94 |
| CHEMBL3645220 | — | — | 1 | 6.85 |
| CHEMBL3645216 | — | — | 1 | 6.30 |
| CHEMBL1650646 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3645224 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3645221 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3645217 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1650657 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1650658 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3645225 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1650647 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1650655 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3645219 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3645223 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3645226 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3645215 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3645218 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3645222 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3645220 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3645216 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1650646 | — | IC50 | = | 840.0 | nM | 6.08 |