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Compound Detail

CHEMBL1650647

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Oc1cccc(-c2ccc3c(-c4ccncc4)c(O)ccc3c2)c1

Basic Information

ChEMBL ID CHEMBL1650647
Phase Preclinical
Structure Type MOL
InChI Key LQVXBXGVWKFEJF-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

313.4
MW (Da)
4.98
ALogP
3
HBA
2
HBD
53.4
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H15NO2
MW 313.36
Aromatic Rings 4
Heavy Atoms 24
NP-Likeness 0.25

Activity Summary

IC50 4 meas. best 7.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
17-beta-hydroxysteroid dehydrogenase type 1
CHEMBL3181
IC50 7.41 7.3 39.0 2
17-beta-hydroxysteroid dehydrogenase type 2
CHEMBL2789
IC50 6.23 5.855 583.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21189020 10.1021/jm1009082 17-beta-hydroxysteroid dehydrogenase type 1 4
21189020 10.1021/jm1009082 17-beta-hydroxysteroid dehydrogenase type 2 3
21189020 10.1021/jm1009082 Estrogen receptor beta 1
21189020 10.1021/jm1009082 Estrogen receptor 1
21189020 10.1021/jm1009082 Unchecked 1

Data from ChEMBL 36 via Core Engine