Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3738571

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against DENV-2 infected in BHK-21 cells assessed as inhibition of virus-induced cytopathogenicity after 3 to 4 days by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Cell Type BHK-21
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Antiviral activity of benzotriazole derivatives. 5-[4-(Benzotriazol-2-yl)phenoxy]-2,2-dimethylpentanoic acids potently and selectively inhibit Coxsackie Virus B5.
Loddo R, Novelli F, Sparatore A, Tasso B, Tonelli M, Boido V, Sparatore F, Collu G, Delogu I, Giliberti G, La Colla P.
Bioorg Med Chem (2015) 23 : 7024 -7034
PubMed 26443549 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 5.26 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL418899 2'-B-METHYL-GUANOSINE 1 5.92
CHEMBL3736249 1 5.10
CHEMBL3734841 1 4.77
CHEMBL3734945 1 -
CHEMBL3736487 1 -
CHEMBL3736357 1 -
CHEMBL3736087 1 -
CHEMBL3735788 1 -
CHEMBL3735299 1 -
CHEMBL3735377 1 -
CHEMBL3735537 1 -
CHEMBL457 GEMFIBROZIL 4.0 1 -
CHEMBL1643 RIBAVIRIN 4.0 1 -
CHEMBL29609 PLECONARIL 2.0 1 -
CHEMBL564201 6-AZAURIDINE 1 -
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE 1 -
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -
CHEMBL3736284 1 -
CHEMBL3734762 1 -
CHEMBL3735768 1 -
CHEMBL3735430 1 -
CHEMBL3735111 1 -
CHEMBL3734874 1 -
CHEMBL3736219 1 -
CHEMBL3735233 1 -
CHEMBL3736258 1 -
CHEMBL3735922 1 -
CHEMBL3734808 1 -
CHEMBL3735807 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL418899 2'-B-METHYL-GUANOSINE EC50 = 1200.0 nM 5.92
CHEMBL3736249 EC50 = 8000.0 nM 5.10
CHEMBL3734841 EC50 = 17000.0 nM 4.77
CHEMBL3735377 EC50 - -
CHEMBL1515627 EC50 - -
CHEMBL3735299 EC50 - -
CHEMBL3735788 EC50 - -
CHEMBL3736087 EC50 - -
CHEMBL3736357 EC50 - -
CHEMBL3736487 EC50 - -
CHEMBL3734945 EC50 - -
CHEMBL3735551 EC50 - -
CHEMBL3735685 EC50 - -
CHEMBL3734886 EC50 - -
CHEMBL3734918 EC50 - -
CHEMBL3736102 EC50 - -
CHEMBL3734848 EC50 - -
CHEMBL3736362 EC50 - -
CHEMBL3736259 EC50 - -
CHEMBL3735011 EC50 - -
CHEMBL3735292 EC50 - -
CHEMBL3735991 EC50 - -
CHEMBL3735768 EC50 - -
CHEMBL3735807 EC50 - -
CHEMBL3734808 EC50 - -
CHEMBL3735922 EC50 - -
CHEMBL3736258 EC50 - -
CHEMBL3735233 EC50 - -
CHEMBL3736219 EC50 - -
CHEMBL3734874 EC50 - -
CHEMBL3735111 EC50 - -
CHEMBL3735430 EC50 - -
CHEMBL3735537 EC50 - -
CHEMBL3734762 EC50 - -
CHEMBL3736284 EC50 - -
CHEMBL184 ACYCLOVIR EC50 - -
CHEMBL866 MYCOPHENOLIC ACID EC50 - -
CHEMBL98778 2'-ETHYNYL-D-CYTIDINE EC50 - -
CHEMBL564201 6-AZAURIDINE EC50 - -
CHEMBL29609 PLECONARIL EC50 - -
CHEMBL1643 RIBAVIRIN EC50 - -
CHEMBL457 GEMFIBROZIL EC50 - -