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Assay Detail

CHEMBL3757730

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes after 5 days
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity.
Pérez-Silanes S, Torres E, Arbillaga L, Varela J, Cerecetto H, González M, Azqueta A, Moreno-Viguri E.
Bioorg Med Chem Lett (2016) 26 : 903 -906
PubMed 26750255 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.44 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3751862 1 6.22
CHEMBL3752067 1 6.00
CHEMBL3752490 1 5.96
CHEMBL3752821 1 5.89
CHEMBL3752856 1 5.70
CHEMBL3753581 1 5.64
CHEMBL3754495 1 5.58
CHEMBL3752880 1 5.28
CHEMBL3754715 1 5.20
CHEMBL3752960 1 5.19
CHEMBL290960 NIFURTIMOX 4.0 1 5.11
CHEMBL110 BENZNIDAZOLE 4.0 1 5.10
CHEMBL3752075 1 4.97
CHEMBL3752598 1 4.92
CHEMBL3752677 1 4.77
CHEMBL3753686 1 -
CHEMBL3754273 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3751862 IC50 = 600.0 nM 6.22
CHEMBL3752067 IC50 = 1000.0 nM 6.00
CHEMBL3752490 IC50 = 1100.0 nM 5.96
CHEMBL3752821 IC50 = 1300.0 nM 5.89
CHEMBL3752856 IC50 = 2000.0 nM 5.70
CHEMBL3753581 IC50 = 2300.0 nM 5.64
CHEMBL3754495 IC50 = 2600.0 nM 5.58
CHEMBL3752880 IC50 = 5300.0 nM 5.28
CHEMBL3754715 IC50 = 6300.0 nM 5.20
CHEMBL3752960 IC50 = 6400.0 nM 5.19
CHEMBL290960 NIFURTIMOX IC50 = 7700.0 nM 5.11
CHEMBL110 BENZNIDAZOLE IC50 = 8000.0 nM 5.10
CHEMBL3752075 IC50 = 10700.0 nM 4.97
CHEMBL3752598 IC50 = 12100.0 nM 4.92
CHEMBL3752677 IC50 = 17000.0 nM 4.77
CHEMBL3753686 IC50 > 25000.0 nM -
CHEMBL3754273 IC50 > 25000.0 nM -