Assay Detail
Binding
CHEMBL3767682
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Antagonist activity at 5HT2A receptor in Sprague-Dawley rat ileum assessed as inhibition of 5-HT-induced contraction
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.66 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763558 | — | — | 1 | 7.91 |
| CHEMBL3765122 | — | — | 1 | 5.93 |
| CHEMBL3764420 | — | — | 1 | 5.79 |
| CHEMBL3763474 | — | — | 1 | 5.37 |
| CHEMBL3765231 | — | — | 1 | 5.01 |
| CHEMBL3765471 | — | — | 1 | 4.99 |
| CHEMBL3764341 | — | — | 1 | 4.63 |
| CHEMBL3763812 | — | — | 1 | - |
| CHEMBL3764080 | — | — | 1 | - |
| CHEMBL3764177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763558 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL3765122 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL3764420 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL3763474 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL3765231 | — | IC50 | = | 9830.0 | nM | 5.01 |
| CHEMBL3765471 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3764341 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL3763812 | — | IC50 | - | — | - | |
| CHEMBL3764080 | — | IC50 | - | — | - | |
| CHEMBL3764177 | — | IC50 | - | — | - |