Compound Detail
CHEMBL3763558
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Basic Information
| ChEMBL ID | CHEMBL3763558 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QEVIFCJESGLVMY-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
393.3
MW (Da)
3.33
ALogP
4
HBA
1
HBD
48.5
PSA (Ų)
0.77
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.97
IC50 1 meas. best 7.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 8.97 | 8.97 | 1.1 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL322 | IC50 | 7.91 | 7.91 | 12.2 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.66 | 6.66 | 219.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Ki | = | 1.07 | nM | 8.97 | Displacement of [3H]ketanserin from 5HT2A receptor in Sprague-Dawley rat brain c... | 26820556 |
| 5-hydroxytryptamine receptor 2A | IC50 | = | 12.2 | nM | 7.91 | Antagonist activity at 5HT2A receptor in Sprague-Dawley rat ileum assessed as in... | 26820556 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 219.0 | nM | 6.66 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain co... | 26820556 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 2A | 3 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 1A | 1 |
| 26820556 | 10.1016/j.ejmech.2016.01.021 | 5-hydroxytryptamine receptor 2C | 1 |
Data from ChEMBL 36 via Core Engine