Assay Detail
Binding
CHEMBL3767686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C receptor in Sprague-Dawley rat brain cortex incubated for 15 mins by liquid scintillation counting analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.61 | 9.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764539 | — | — | 1 | 9.81 |
| CHEMBL104593 | — | — | 1 | 9.03 |
| CHEMBL12314 | MESULERGINE | 2.0 | 1 | 8.72 |
| CHEMBL3764390 | — | — | 1 | 8.66 |
| CHEMBL3763242 | — | — | 1 | 8.65 |
| CHEMBL3765463 | — | — | 1 | 8.29 |
| CHEMBL3763714 | — | — | 1 | 8.17 |
| CHEMBL3763474 | — | — | 1 | 7.67 |
| CHEMBL3765471 | — | — | 1 | 7.54 |
| CHEMBL3764666 | — | — | 1 | 7.53 |
| CHEMBL3764761 | — | — | 1 | 7.26 |
| CHEMBL3763812 | — | — | 1 | 7.00 |
| CHEMBL3764925 | — | — | 1 | 6.72 |
| CHEMBL3764313 | — | — | 1 | 6.48 |
| CHEMBL3764752 | — | — | 1 | 6.42 |
| CHEMBL192242 | — | — | 1 | 5.88 |
| CHEMBL3765797 | — | — | 1 | 5.51 |
| CHEMBL3763429 | — | — | 1 | - |
| CHEMBL3763558 | — | — | 1 | - |
| CHEMBL3764341 | — | — | 1 | - |
| CHEMBL3765273 | — | — | 1 | - |
| CHEMBL3764420 | — | — | 1 | - |
| CHEMBL3764009 | — | — | 1 | - |
| CHEMBL3764177 | — | — | 1 | - |
| CHEMBL3763629 | — | — | 1 | - |
| CHEMBL3763331 | — | — | 1 | - |
| CHEMBL3765643 | — | — | 1 | - |
| CHEMBL3763834 | — | — | 1 | - |
| CHEMBL3764284 | — | — | 1 | - |
| CHEMBL3764575 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764539 | — | Ki | = | 0.156 | nM | 9.81 |
| CHEMBL104593 | — | Ki | = | 0.933 | nM | 9.03 |
| CHEMBL12314 | MESULERGINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3764390 | — | Ki | = | 2.19 | nM | 8.66 |
| CHEMBL3763242 | — | Ki | = | 2.23 | nM | 8.65 |
| CHEMBL3765463 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL3763714 | — | Ki | = | 6.79 | nM | 8.17 |
| CHEMBL3763474 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL3765471 | — | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL3764666 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL3764761 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL3763812 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3764925 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL3764313 | — | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL3764752 | — | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL192242 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL3765797 | — | Ki | = | 3080.0 | nM | 5.51 |
| CHEMBL3764074 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764772 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763633 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765122 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765231 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765362 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765622 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764080 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765470 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764534 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765808 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764575 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764284 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763834 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765643 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763331 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763629 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764177 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764009 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764420 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3765273 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3764341 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763558 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3763429 | — | Ki | > | 10000.0 | nM | - |