Assay Detail
ADMET
CHEMBL3863977
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Antagonist activity at adenosine A2a receptor (unknown origin)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.24 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3918173 | — | — | 1 | 8.30 |
| CHEMBL3916846 | — | — | 1 | 8.05 |
| CHEMBL3941513 | — | — | 1 | 7.66 |
| CHEMBL3980193 | — | — | 1 | 7.55 |
| CHEMBL3986586 | — | — | 1 | 7.48 |
| CHEMBL3952586 | — | — | 1 | 7.48 |
| CHEMBL3968147 | — | — | 1 | 7.39 |
| CHEMBL3896989 | — | — | 1 | 7.23 |
| CHEMBL3957127 | — | — | 1 | 7.07 |
| CHEMBL3905929 | — | — | 1 | 6.98 |
| CHEMBL3969954 | — | — | 1 | 6.78 |
| CHEMBL3963331 | — | — | 1 | 6.57 |
| CHEMBL3903604 | — | — | 1 | 6.48 |
| CHEMBL3950249 | — | — | 1 | 6.36 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | - |
| CHEMBL3985784 | — | — | 1 | - |
| CHEMBL3948448 | — | — | 1 | - |
| CHEMBL3977665 | — | — | 1 | - |
| CHEMBL3913876 | — | — | 1 | - |
| CHEMBL3941862 | — | — | 1 | - |
| CHEMBL3945895 | — | — | 1 | - |
| CHEMBL3903408 | — | — | 1 | - |
| CHEMBL3922464 | — | — | 1 | - |
| CHEMBL3919325 | — | — | 1 | - |
| CHEMBL3955694 | — | — | 1 | - |
| CHEMBL3984510 | — | — | 1 | - |
| CHEMBL3892121 | — | — | 1 | - |
| CHEMBL3984674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3918173 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3916846 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3941513 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3980193 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3986586 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3952586 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3968147 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3896989 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3957127 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3905929 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL3969954 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3963331 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3903604 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL3950249 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL193240 | ROFLUMILAST | IC50 | > | 1000.0 | nM | - |
| CHEMBL3985784 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3948448 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3977665 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3913876 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3941862 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3945895 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3903408 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3922464 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3919325 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3955694 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3984510 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3892121 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3984674 | — | IC50 | - | — | - |