Compound Detail
CHEMBL3905929
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CCn1nc(-c2cccc(-c3ccc(CC(=O)NCCN4CCCCC4)cc3)c2)cc(NC(=O)Nc2c(Cl)cncc2Cl)c1=O
Basic Information
| ChEMBL ID | CHEMBL3905929 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQZLVDUQQNPSEH-UHFFFAOYSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
648.6
MW (Da)
6.09
ALogP
7
HBA
3
HBD
121.2
PSA (Ų)
0.19
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 10.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 10.3 | 10.3 | 0.1 | 1 |
| Unchecked CHEMBL612545 | IC50 | 9.28 | 7.855 | 0.5 | 2 |
| Adenosine receptor A1 CHEMBL226 | IC50 | 7.51 | 7.51 | 31.0 | 1 |
| Adenosine receptor A2b CHEMBL255 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
| Adenosine receptor A2a CHEMBL251 | IC50 | 6.98 | 6.98 | 105.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 0.05 | nM | 10.3 | Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydroly... | 27933955 |
| Unchecked | IC50 | = | 0.52 | nM | 9.28 | Inhibition of PDE4 in PBMC (unknown origin) assessed as reduction in LPS-induced... | 27933955 |
| Adenosine receptor A1 | IC50 | = | 31.0 | nM | 7.51 | Antagonist activity at adenosine A1 receptor (unknown origin) | 27933955 |
| Adenosine receptor A2b | IC50 | = | 90.0 | nM | 7.05 | Antagonist activity at adenosine A2b receptor (unknown origin) | 27933955 |
| Adenosine receptor A2a | IC50 | = | 105.0 | nM | 6.98 | Antagonist activity at adenosine A2a receptor (unknown origin) | 27933955 |
| Unchecked | IC50 | = | 374.0 | nM | 6.43 | Inhibition of PDE4 in human whole blood assessed as reduction in LPS-induced TNF... | 27933955 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Rattus norvegicus | 7 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Unchecked | 2 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A2a | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A1 | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Adenosine receptor A2b | 1 |
Data from ChEMBL 36 via Core Engine