Assay Detail
Functional
CHEMBL3874983
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Agonist activity at human GPR120 short isoform expressed in CHOK1 cells assessed as induction of IP1 accumulation after 60 mins by HTRF assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.98 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3919973 | — | — | 1 | 7.01 |
| CHEMBL3891920 | — | — | 1 | 6.89 |
| CHEMBL3973034 | — | — | 1 | 6.70 |
| CHEMBL3893026 | — | — | 1 | 6.66 |
| CHEMBL3953289 | — | — | 1 | 6.44 |
| CHEMBL3901994 | — | — | 1 | 6.38 |
| CHEMBL3940359 | — | — | 1 | 6.36 |
| CHEMBL3947837 | — | — | 1 | 5.92 |
| CHEMBL3977361 | — | — | 1 | 5.68 |
| CHEMBL3949142 | — | — | 1 | 5.66 |
| CHEMBL3897637 | — | — | 1 | 5.57 |
| CHEMBL3954140 | — | — | 1 | 5.51 |
| CHEMBL3937916 | — | — | 1 | 5.48 |
| CHEMBL3928591 | — | — | 1 | 5.46 |
| CHEMBL3969920 | — | — | 1 | 5.39 |
| CHEMBL3967504 | — | — | 1 | 5.37 |
| CHEMBL3986483 | — | — | 1 | 5.24 |
| CHEMBL3920891 | — | — | 1 | - |
| CHEMBL3957767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3919973 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3891920 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3973034 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3893026 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3953289 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3901994 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3940359 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3947837 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3977361 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3949142 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3897637 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3954140 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3937916 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3928591 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3969920 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3967504 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3986483 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3920891 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3957767 | — | EC50 | > | 10000.0 | nM | - |