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Assay Detail

CHEMBL3881497

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Binding
Binding affinity to immobilized human TFPI-1alpha using biotinylated compound incubated for 1.5 hrs by measuring horseradish peroxidase-conjugated streptavidin-mediated conversion of TMB substrate by ELISA
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tissue factor pathway inhibitor (CHEMBL3713062) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

TFPI inhibitors and methods of use
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 47 8.02 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3966351 — — 1 9.00
CHEMBL3894045 — — 1 8.85
CHEMBL3965493 — — 1 8.77
CHEMBL3978593 — — 1 8.66
CHEMBL3980958 — — 1 7.78
CHEMBL3953204 — — 1 6.82
CHEMBL3910518 — — 1 6.24
CHEMBL3918572 — — 1 -
CHEMBL3981290 — — 1 -
CHEMBL3921292 — — 1 -
CHEMBL3955215 — — 1 -
CHEMBL3907713 — — 1 -
CHEMBL3959676 — — 1 -
CHEMBL3955843 — — 1 -
CHEMBL3979709 — — 1 -
CHEMBL3899025 — — 1 -
CHEMBL3896345 — — 1 -
CHEMBL3910006 — — 1 -
CHEMBL3967934 — — 1 -
CHEMBL3956163 — — 1 -
CHEMBL3906847 — — 1 -
CHEMBL3966877 — — 1 -
CHEMBL3918432 — — 1 -
CHEMBL3940379 — — 1 -
CHEMBL3973898 — — 1 -
CHEMBL3908160 — — 1 -
CHEMBL3986750 — — 1 -
CHEMBL3963690 — — 1 -
CHEMBL3941812 — — 1 -
CHEMBL3955549 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3966351 — EC50 = 1.0 nM 9.00
CHEMBL3894045 — EC50 = 1.4 nM 8.85
CHEMBL3965493 — EC50 = 1.7 nM 8.77
CHEMBL3978593 — EC50 = 2.2 nM 8.66
CHEMBL3980958 — EC50 = 16.8 nM 7.78
CHEMBL3953204 — EC50 = 152.3 nM 6.82
CHEMBL3910518 — EC50 = 574.8 nM 6.24
CHEMBL3914919 — EC50 < 10000.0 nM -
CHEMBL3896345 — EC50 < 10000.0 nM -
CHEMBL3965139 — EC50 < 10000.0 nM -
CHEMBL3940709 — EC50 < 10000.0 nM -
CHEMBL3902569 — EC50 < 10000.0 nM -
CHEMBL3937894 — EC50 < 10000.0 nM -
CHEMBL3912278 — EC50 < 10000.0 nM -
CHEMBL3981290 — EC50 < 10000.0 nM -
CHEMBL3910006 — EC50 < 10000.0 nM -
CHEMBL3951238 — EC50 < 10000.0 nM -
CHEMBL3900537 — EC50 < 10000.0 nM -
CHEMBL3907724 — EC50 < 10000.0 nM -
CHEMBL3968265 — EC50 < 10000.0 nM -
CHEMBL3896444 — EC50 < 10000.0 nM -
CHEMBL3910529 — EC50 < 10000.0 nM -
CHEMBL3923656 — EC50 < 10000.0 nM -
CHEMBL3938403 — EC50 < 10000.0 nM -
CHEMBL3937166 — EC50 < 10000.0 nM -
CHEMBL3935617 — EC50 < 10000.0 nM -
CHEMBL3953920 — EC50 < 10000.0 nM -
CHEMBL3906847 — EC50 < 10000.0 nM -
CHEMBL3955549 — EC50 < 10000.0 nM -
CHEMBL3941812 — EC50 > 1000.0 nM -
CHEMBL3963690 — EC50 < 10000.0 nM -
CHEMBL3986750 — EC50 < 10000.0 nM -
CHEMBL3908160 — EC50 < 10000.0 nM -
CHEMBL3973898 — EC50 < 10000.0 nM -
CHEMBL3940379 — EC50 < 10000.0 nM -
CHEMBL3918432 — EC50 < 10000.0 nM -
CHEMBL3966877 — EC50 < 10000.0 nM -
CHEMBL3899025 — EC50 < 10000.0 nM -
CHEMBL3956163 — EC50 < 10000.0 nM -
CHEMBL3967934 — EC50 < 10000.0 nM -
CHEMBL3918572 — EC50 < 10000.0 nM -
CHEMBL3921292 — EC50 < 10000.0 nM -
CHEMBL3955215 — EC50 < 10000.0 nM -
CHEMBL3907713 — EC50 < 10000.0 nM -
CHEMBL3959676 — EC50 > 25000.0 nM -
CHEMBL3955843 — EC50 > 5000.0 nM -
CHEMBL3979709 — EC50 < 10000.0 nM -