Compound Detail
CHEMBL3965493
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Basic Information
| ChEMBL ID | CHEMBL3965493 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NFTWPDCTKXPVNZ-IIFWUBCPSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
4308.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tissue factor pathway inhibitor CHEMBL3713062 | EC50 | 8.77 | 6.9433 | 1.7 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tissue factor pathway inhibitor | EC50 | = | 1.7 | nM | 8.77 | Binding affinity to immobilized human TFPI-1alpha using biotinylated compound in... | - |
| Tissue factor pathway inhibitor | EC50 | = | 530.0 | nM | 6.28 | Inhibition of TFPI (unknown origin) using FXa-specific chromogenic substrate S22... | - |
| Tissue factor pathway inhibitor | EC50 | = | 1670.0 | nM | 5.78 | Inhibition of TFPI (unknown origin) using FXa-specific chromogenic substrate S22... | - |
Data from ChEMBL 36 via Core Engine