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Assay Detail

CHEMBL3999948

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen strain C2C4 amastigote forms harboring LacZ infected in rat L6 cells after 96 hrs by CPRG/Nonidet reagent based photometric method
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Synthesis and activity of nucleoside-based antiprotozoan compounds.
Tran HA, Zheng Z, Wen X, Manivannan S, Pastor A, Kaiser M, Brun R, Snyder FF, Back TG.
Bioorg Med Chem (2017) 25 : 2091 -2104
PubMed 28284860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 4.69 5.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL110 BENZNIDAZOLE 4.0 1 5.79
CHEMBL4088825 1 5.58
CHEMBL4062813 1 5.47
CHEMBL3799380 1 5.15
CHEMBL4074699 1 5.00
CHEMBL4075657 1 4.89
CHEMBL4060076 1 4.85
CHEMBL4091995 1 4.82
CHEMBL4066090 1 4.82
CHEMBL3799944 1 4.70
CHEMBL4071448 1 4.68
CHEMBL4081985 1 4.66
CHEMBL4096088 1 4.60
CHEMBL4093664 1 4.46
CHEMBL4090399 1 4.46
CHEMBL4070000 1 4.41
CHEMBL3798486 1 4.35
CHEMBL4090762 1 4.15
CHEMBL4093177 1 4.13
CHEMBL4084731 1 4.12
CHEMBL2113602 1 4.06
CHEMBL4076818 1 4.03
CHEMBL4068736 1 -
CHEMBL4089844 1 -
CHEMBL4067099 1 -
CHEMBL4088363 1 -
CHEMBL4069803 1 -
CHEMBL3800333 1 -
CHEMBL4080501 1 -
CHEMBL3799739 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL110 BENZNIDAZOLE IC50 = 1640.0 nM 5.79
CHEMBL4088825 IC50 = 2600.0 nM 5.58
CHEMBL4062813 IC50 = 3400.0 nM 5.47
CHEMBL3799380 IC50 = 7100.0 nM 5.15
CHEMBL4074699 IC50 = 10000.0 nM 5.00
CHEMBL4075657 IC50 = 13000.0 nM 4.89
CHEMBL4060076 IC50 = 14000.0 nM 4.85
CHEMBL4091995 IC50 = 15000.0 nM 4.82
CHEMBL4066090 IC50 = 15000.0 nM 4.82
CHEMBL3799944 IC50 = 20000.0 nM 4.70
CHEMBL4071448 IC50 = 21000.0 nM 4.68
CHEMBL4081985 IC50 = 22000.0 nM 4.66
CHEMBL4096088 IC50 = 25000.0 nM 4.60
CHEMBL4093664 IC50 = 35000.0 nM 4.46
CHEMBL4090399 IC50 = 35000.0 nM 4.46
CHEMBL4070000 IC50 = 39000.0 nM 4.41
CHEMBL3798486 IC50 = 45000.0 nM 4.35
CHEMBL4090762 IC50 = 71000.0 nM 4.15
CHEMBL4093177 IC50 = 74000.0 nM 4.13
CHEMBL4084731 IC50 = 76000.0 nM 4.12
CHEMBL2113602 IC50 = 88000.0 nM 4.06
CHEMBL4076818 IC50 = 93000.0 nM 4.03
CHEMBL4099742 IC50 > 270000.0 nM -
CHEMBL4061466 IC50 = 106000.0 nM -
CHEMBL4076721 IC50 > 260000.0 nM -
CHEMBL4097315 IC50 > 200000.0 nM -
CHEMBL4085214 IC50 = 156000.0 nM -
CHEMBL4105508 IC50 = 106000.0 nM -
CHEMBL4095187 IC50 = 144000.0 nM -
CHEMBL4091532 IC50 = 103000.0 nM -
CHEMBL4100225 IC50 = 101000.0 nM -
CHEMBL4094270 IC50 = 178000.0 nM -
CHEMBL3797470 IC50 = 195000.0 nM -
CHEMBL4065059 IC50 = 191000.0 nM -
CHEMBL3799313 IC50 = 147000.0 nM -
CHEMBL4102936 IC50 = 157000.0 nM -
CHEMBL4076916 IC50 = 161000.0 nM -
CHEMBL3799800 IC50 > 340000.0 nM -
CHEMBL3797375 IC50 = 189000.0 nM -
CHEMBL4085977 IC50 = 125000.0 nM -
CHEMBL3800167 IC50 = 120000.0 nM -
CHEMBL4073644 IC50 = 174000.0 nM -
CHEMBL3799739 IC50 = 126000.0 nM -
CHEMBL4080501 IC50 = 104000.0 nM -
CHEMBL3800333 IC50 = 144000.0 nM -
CHEMBL4069803 IC50 = 150000.0 nM -
CHEMBL4088363 IC50 = 109000.0 nM -
CHEMBL4067099 IC50 = 113000.0 nM -
CHEMBL4089844 IC50 = 129000.0 nM -
CHEMBL4068736 IC50 = 114000.0 nM -