Assay Detail
Binding
CHEMBL4001852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]5-HT uptake by SERT primary site (S1) (unknown origin) expressed in African green monkey COS1 cells after 10 mins by TopCount scintillation counting method
17
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.40 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072807 | — | — | 1 | 8.80 |
| CHEMBL1508 | ESCITALOPRAM | 4.0 | 1 | 8.68 |
| CHEMBL4093518 | — | — | 1 | 8.40 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.17 |
| CHEMBL4064213 | — | — | 1 | 8.10 |
| CHEMBL4070493 | — | — | 3 | 8.00 |
| CHEMBL4085773 | — | — | 1 | 7.92 |
| CHEMBL4062666 | — | — | 1 | 7.89 |
| CHEMBL399730 | (R)-CITALOPRAM | — | 1 | 6.77 |
| CHEMBL4061866 | — | — | 3 | 6.60 |
| CHEMBL4071311 | — | — | 3 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072807 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1508 | ESCITALOPRAM | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4093518 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL549 | CITALOPRAM | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4064213 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4070493 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4085773 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4062666 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4070493 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4070493 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL399730 | (R)-CITALOPRAM | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4061866 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4061866 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4071311 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4071311 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4071311 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4061866 | — | IC50 | = | 740.0 | nM | 6.13 |